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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1467-0.1 | 100 µg | - |
3 - 11 business days* |
580.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD84 is a highly glycosylated homophilic receptor of SLAM family. It is expressed on platelets... more
Product information "Anti-CD84 Monoclonal Antibody (Clone:CD84.1.21)"
CD84 is a highly glycosylated homophilic receptor of SLAM family. It is expressed on platelets and various types of leukocytes, especially following their activation. Ligation of CD84 leads to its phosphorylation on tyrosine residues within the cytoplasmic tail. These docking sites are recognized by downstream signaling molecules, such as phosphatase SHP-2 and adaptor protein SAP/SH2D1A. The function of CD84 has not been fully elucidated yet. Although predominantly activating receptor, its modulating activity was also demonstrated. Protein function: Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B. Increases proliferative responses of activated T- cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780, PubMed:12115647. PubMed:12928397, PubMed:12962726, PubMed:16037392) Required for a prolonged T- cell:B-cell contact, optimal T follicular helper function, and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity. In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling, independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF- kappaB activation and modulates LPS-induced cytokine secretion, involving ITSM 2. Positively regulates macroautophagy in primary dendritic cells via stabilization of IRF8, inhibits TRIM21-mediated proteasomal degradation of IRF8 (PubMed:29434592). [The UniProt Consortium]
Keywords: | Anti-CD84, Anti-SLAMF5, Anti-Hly9-beta, Anti-SLAM family member 5, Anti-Cell surface antigen MAX.3, Anti-Leukocyte differentiation antigen CD84, Anti-Signaling lymphocytic activation molecule 5, Anti-CD84 Monoclonal Antibody (Clone:CD84.1.21) |
Supplier: | Abeomics |
Supplier-Nr: | 30-1467 |
Properties
Application: | FC, IP, FA |
Antibody Type: | Monoclonal |
Clone: | CD84.1.21 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | CD84-transfected 300.19 cell line |
Format: | Affinity Purified |
Database Information
KEGG ID : | K06511 | Matching products |
UniProt ID : | Q9UIB8 | Matching products |
Gene ID | GeneID 8832 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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