Anti-CD81 Monoclonal Antibody (Clone:M38)-APC Conjugated

CD81 (TAPA-1), a member of the tetraspanin family, is expressed on virtually all nucleated cells, but above all on germinal center B cells. CD81 forms complexes with other tetraspanin proteins, integrins, coreceptors, MHC class I and II molecules, and influences adhesion, morphology, activation, proliferation and differentiation of B, T and other cells - e.g. in muscles CD81 promotes cell fusion and myotube maintenance. CD81 has been also identified as a receptor for the hepatitis C virus. Protein function: Required for normal cell surface expression of CD19 and for normal adaptive immune responses (PubMed:20237408, PubMed:27881302). Required for normal female fertility and normal sperm-egg fusion. May be involved in the acrosome reaction. Can inhibit the proliferation of a subset of cultured lymphoma cell lines (PubMed:1695320, PubMed:2398277). [The UniProt Consortium]