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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1798-100 | 100 tests | - |
3 - 11 business days* |
713.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are... more
Product information "Anti-CD79b Monoclonal Antibody (Clone:CB3-1)-APC Conjugated"
CD79b (Ig beta, B29) forms disulfide-linked heterodimer with CD79a (Ig alpha, MB1). They both are transmembrane proteins with extended cytoplasmic domains containing immunoreceptor tyrosine activation motives (ITAMs), and together with cell surface immunoglobulin they constitute B-cell antigen-specific receptor (BCR). CD79a and b are the first components of BCR that are expressed developmentally. They appear on pro-B cells in association with the endoplasmic reticulum chaperone calnexin. Subsequently, in pre-B cells, CD79 heterodimer is associated with lambda5-VpreB surrogate immunoglobulin and later with antigen-specific surface immunoglobulins. CD79a/b complex interacts with Src-family tyrosine kinase Lyn, which phosphorylates its cytoplasmic ITAM motives to form docking sites for downstream signaling. Protein function: Required in cooperation with CD79A for initiation of the signal transduction cascade activated by the B-cell antigen receptor complex (BCR) which leads to internalization of the complex, trafficking to late endosomes and antigen presentation. Enhances phosphorylation of CD79A, possibly by recruiting kinases which phosphorylate CD79A or by recruiting proteins which bind to CD79A and protect it from dephosphorylation. [The UniProt Consortium]
Keywords: | Anti-B29, Anti-CD79b, Anti-CD79B, Anti-Ig-beta, Anti-B-cell-specific glycoprotein B29, Anti-Immunoglobulin-associated B29 protein, Anti-B-cell antigen receptor complex-associated protein beta chain, Anti-CD79b Monoclonal Antibody (Clone:CB3-1)-APC Conjuga |
Supplier: | Abeomics |
Supplier-Nr: | 30-1798 |
Properties
Application: | FC, IP, WB |
Antibody Type: | Monoclonal |
Clone: | CB3-1 |
Conjugate: | APC |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Fraction of Ig-associated molecules isolated from Ramos B cells |
Database Information
KEGG ID : | K06507 | Matching products |
UniProt ID : | P40259 | Matching products |
Gene ID | GeneID 974 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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