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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V8262SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in 1X PBS, BSA free, sodium azide free. CD5 has been identified as a transmembrane... more
Product information "Anti-CD72, clone BU40"
1 mg/ml in 1X PBS, BSA free, sodium azide free. CD5 has been identified as a transmembrane glycoprotein that is expressed on 70% of normal peripheral blood lymphocytes and on virtually all T lymphocytes in thymus and peripheral blood. Activation of T cells through the T cell receptor (TCR) results in tyrosine phosphorylation of CD5, and the absence of CD5 renders T cells hyper-responsive to TCR-mediated activation. CD5 associates with the TCR/CD3 chain, and with the Src family kinase, Lck p56. The C-type lectin superfamily member CD72 is a cell surface negative regulator of B cell activation from the pro-B through the mature B cell stage. CD72 serves as a receptor for CD5. The ability of lymphocytes to respond to antigenic or mitogenic stimulation utilizes both positive and negative regulatory proteins that influence the threshold for responsiveness. The human CD72 gene maps to chromosome 9p13.3 and encodes a transmembrane glycoprotein that contains an ITIM. Upon tyrosine phosphorylation, the CD72 ITIM recruits SH2-containing phosphatases such as SHP-1, resulting in downregulation of cell activation. CD72-/- mice contain hyperproliferative B cells. Protein function: Plays a role in B-cell proliferation and differentiation. [The UniProt Consortium]
Keywords: | Anti-CD72, Anti-Lyb-2, Anti-B-cell differentiation antigen CD72, CD72 Antibody |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V8262SAF |
Properties
Application: | FC, IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | BU40 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | The HF B1 plasmacytoid cell line |
Format: | Purified |
Database Information
KEGG ID : | K06504 | Matching products |
UniProt ID : | P21854 | Matching products |
Gene ID | GeneID 971 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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