Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay10004597-1 | 1 each | - |
6 - 10 business days* |
422.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD45 is a type I transmembrane glycoprotein that is encoded by the PTPRC gene in humans and is... more
Product information "Anti-CD45 (Clone BRA-55)"
CD45 is a type I transmembrane glycoprotein that is encoded by the PTPRC gene in humans and is abundantly expressed on nucleated hematopoietic cells. It contains an extracellular region that binds to glycoproteins and exists in various isoforms in a cell type-, differentiation state-, and activation state-dependent manner. CD45 also contains two highly conserved cytoplasmic protein tyrosine phosphatase domains that regulate intracellular signaling. CD45 functions as a negative or positive regulator of antigen receptor signaling in T and B cells through dephosphorylation of Src family kinases in a cell type- and differentiation state-dependent manner. It also dephosphorylates JAK kinases, inhibiting cytokine and chemokine signaling in leukocytes. Mutations in PTPRC are associated with severe combined immunodeficiency (SCID) in mice and humans. The number of CD45+ cells is increased in postmortem brain from patients with Alzheimer's disease. Increased levels of the CD45 isoform CD45RO have been found on CD19+ lamina propria B cells isolated from patients with Crohn's disease. Fluorescently labeled versions of CD45 have commonly been used in flow cytometry as a pan leukocyte marker and to identify certain subsets of hematopoietic stem cells (HSCs). Cayman's CD45 Monoclonal Antibody (Clone BRA-55) can be used for flow cytometry (FC), immunocytochemistry (ICC), immunohistochemistry (IHC), and Western blot (WB) applications. The antibody recognizes CD45 at approximately 170 to 220 kDa from human samples.Synonyms: LCA, Leukocyte Common Antigen, Ly-5, PTPRC. Immunogen: Human CD45. Clone Designation: BRA-55. MW: 170-220 kDa. Formulation: (Request formulation change), 100 µg of protein A-affinity purified monoclonal antibody. Storage Buffer: 500 µl PBS, pH 7.2, with 0.02% sodium azide. Host: Mouse. Isotype: IgG1. Applications: FC, ICC, IHC, WB. Origin: Animal/Mouse.
Keywords: | LCA, Leukocyte Common Antigen, Ly-5, PTPRC |
Supplier: | Cayman Chemical |
Supplier-Nr: | 10004597 |
Properties
Application: | FC, ICC, IHC, WB |
Antibody Type: | Monoclonal |
Clone: | BRA-55 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Human CD45 |
Format: | Purified |
Database Information
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed