Anti-CD44 (HCAM), clone HCAM/1097

Anti-CD44 (HCAM), clone HCAM/1097
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3013SAF-100UG 100 µg - -

3 - 10 business days

541.00€
 
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a cell surface glycoprotein of... more
Product information "Anti-CD44 (HCAM), clone HCAM/1097"
1 mg/ml in sterile PBS, BSA free, sodium azide free. Recognizes a cell surface glycoprotein of 80-95kDa (CD44/HCAM) on lymphocytes, monocytes, and granulocytes. The CD44 family of glycoproteins exists in a number of variant isoforms, the most common being the standard 85-95kDa or hematopoietic variant (CD44s). Higher molecular weight isoforms are described in epithelial cells (CD44v), which are believed to function in intercellular adhesion and stromal binding. CD44/HCAM immunostaining is commonly used for the discrimination of urothelial transitional cell carcinoma in-situ from non-neoplastic changes in the urothelium. Protein function: Receptor for hyaluronic acid (HA). Mediates cell-cell and cell-matrix interactions through its affinity for HA, and possibly also through its affinity for other ligands such as osteopontin, collagens, and matrix metalloproteinases (MMPs). Adhesion with HA plays an important role in cell migration, tumor growth and progression. In cancer cells, may play an important role in invadopodia formation. Also involved in lymphocyte activation, recirculation and homing, and in hematopoiesis. Altered expression or dysfunction causes numerous pathogenic phenotypes. Great protein heterogeneity due to numerous alternative splicing and post-translational modification events. Receptor for LGALS9, the interaction enhances binding of SMAD3 to the FOXP3 promoter, leading to up-regulation of FOXP3 expression and increased induced regulatory T (iTreg) cell stability and suppressive function. [The UniProt Consortium]
Keywords: Anti-LHR, Anti-CD44, Anti-PGP-1, Anti-CDw44, Anti-PGP-I, Anti-Epican, Anti-HUTCH-I, Anti-ECMR-III, Anti-CD44 antigen, Anti-Hermes antigen, Anti-Hyaluronate receptor, Anti-Phagocytic glycoprotein I, Anti-Phagocytic glycoprotein 1, CD44 Antibody (HCAM)
Supplier: NSJ Bioreagents
Supplier-Nr: V3013SAF-100UG

Properties

Application: FC, IF, IHC (paraffin)
Antibody Type: Monoclonal
Clone: HCAM/1097
Conjugate: No
Host: Mouse
Reactivity: Human, Mouse
Immunogen: Recombinant human HCAM protein
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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