Anti-CD44

Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-66948.60 60 µl -

7 - 16 business days*

198.00€
E-AB-66948.120 120 µl -

7 - 16 business days*

317.00€
E-AB-66948.200 200 µl -

7 - 16 business days*

525.00€
 
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell... more
Product information "Anti-CD44"
The protein encoded by this gene is a cell-surface glycoprotein involved in cell-cell interactions, cell adhesion and migration. It is a receptor for hyaluronic acid (HA) and can also interact with other ligands, such as osteopontin, collagens, and matrix metalloproteinases (MMPs). This protein participates in a wide variety of cellular functions including lymphocyte activation, recirculation and homing, hematopoiesis, and tumor metastasis. Transcripts for this gene undergo complex alternative splicing that results in many functionally distinct isoforms, however, the full length nature of some of these variants has not been determined. Alternative splicing is the basis for the structural and functional diversity of this protein, and may be related to tumor metastasis. Protein function: Cell-surface receptor that plays a role in cell-cell interactions, cell adhesion and migration, helping them to sense and respond to changes in the tissue microenvironment (PubMed:16541107, PubMed:19703720, PubMed:22726066). Participates thereby in a wide variety of cellular functions including the activation, recirculation and homing of T-lymphocytes, hematopoiesis, inflammation and response to bacterial infection (PubMed:7528188). Engages, through its ectodomain, extracellular matrix components such as hyaluronan/HA, collagen, growth factors, cytokines or proteases and serves as a platform for signal transduction by assembling, via its cytoplasmic domain, protein complexes containing receptor kinases and membrane proteases (PubMed:18757307, PubMed:23589287). Such effectors include PKN2, the RhoGTPases RAC1 and RHOA, Rho-kinases and phospholipase C that coordinate signaling pathways promoting calcium mobilization and actin-mediated cytoskeleton reorganization essential for cell migration and adhesion (PubMed:15123640). [The UniProt Consortium]
Keywords: Anti-LHR, Anti-CD44, Anti-PGP-I, Anti-CDw44, Anti-PGP-1, Anti-Epican, Anti-HUTCH-I, Anti-ECMR-III, Anti-CD44 antigen, Anti-Hermes antigen, Anti-Hyaluronate receptor, Anti-Phagocytic glycoprotein 1, Anti-Phagocytic glycoprotein I, CD44 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-66948

Properties

Application: IHC, IF
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant fusion protein of human CD44 (NP_000601.3).

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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