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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES8786.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES8786.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a... more
Product information "Anti-CD42c"
Platelet glycoprotein Ib (GPIb) is a heterodimeric transmembrane protein consisting of a disulfide-linked 140 kD alpha chain and 22 kD beta chain. It is part of the GPIb-V-IX system that constitutes the receptor for von Willebrand factor (VWF), and mediates platelet adhesion in the arterial circulation. GPIb alpha chain provides the VWF binding site, and GPIb beta contributes to surface expression of the receptor and participates in transmembrane signaling through phosphorylation of its intracellular domain. Mutations in the GPIb beta subunit have been associated with Bernard-Soulier syndrome, velocardiofacial syndrome and giant platelet disorder. The 206 amino acid precursor of GPIb beta is synthesized from a 1.0 kb mRNA expressed in plateletes and megakaryocytes. A 411 amino acid protein arising from a longer, unspliced transcript in endothelial cells has been described, however, t Protein function: Gp-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to von Willebrand factor, which is already bound to the subendothelium. [The UniProt Consortium] Recommended dilutions: IHC-p 1:50-200, ELISA 1:10000-20000. Cellular localization: Membrane, Single-pass type I membrane protein.
Keywords: | Anti-GPIbB, Anti-CD42c, Anti-GP1BB, Anti-GPIb-beta, Anti-GP-Ib beta, Anti-Antigen CD42b-beta, Anti-Platelet glycoprotein Ib beta chain, CD42c rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES8786 |
Properties
Application: | IHC, IF, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Synthetic peptide from human protein at AA range: 90-150 |
Format: | Purified |
Database Information
KEGG ID : | K06262 | Matching products |
UniProt ID : | P13224 | Matching products |
Gene ID | GeneID 2812 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
You will get a certificate here
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