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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-30-1728-100 | 100 tests | - |
3 - 11 business days* |
713.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated... more
Product information "Anti-CD20 Monoclonal Antibody (Clone:LT20)-APC Conjugated"
CD20 is a cell surface 33-37 (depending on the degree of phosphorylation) kDa non-glycosylated surface phosphoprotein expressed on mature and most malignant B cells, but not stem cells or plasma cells (low number of the CD20 has been also detected on a subpopulation of T lymphocytes and it can be expressed on follicular dendritic cells). Its expression on B cells is synchronous with the expression of surface IgM. CD20 regulates transmembrane calcium conductance (probably functioning as a component of store-operated calcium channel), cell cycle progression and B-cell proliferation. It is associated with lipid rafts, but the intensity of this association depends on extracellular triggering, employing CD20 conformational change and/or BCR (B cell antigen receptor) aggregation. After the receptor ligation, BCR and CD20 colocalize and then rapidly dissociate before BCR endocytosis, whereas CD20 remains at the cell surface. CD20 serves as a useful target for antibody-mediated therapeutic depletion of B cells, as it is expressed at high levels on most B-cell malignancies, but does not become internalized or shed from the plasma membrane following mAb treatment. Protein function: This protein may be involved in the regulation of B-cell activation and proliferation. [The UniProt Consortium]
Keywords: | Anti-Bp35, Anti-CD20, Anti-MS4A1, Anti-B-lymphocyte antigen CD20, Anti-B-lymphocyte surface antigen B1, Anti-Leukocyte surface antigen Leu-16, Anti-Membrane-spanning 4-domains subfamily A member 1, Anti-CD20 Monoclonal Antibody (Clone:LT20)-APC Conjugated |
Supplier: | Abeomics |
Supplier-Nr: | 30-1728 |
Properties
Application: | FC |
Antibody Type: | Monoclonal |
Clone: | LT20 |
Conjugate: | APC |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Normal human lymphocytes from lymph node. |
Database Information
KEGG ID : | K06466 | Matching products |
UniProt ID : | P11836 | Matching products |
Gene ID | GeneID 931 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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