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HEI10 is a member of the E3 ubiquitin ligase family and functions in progression of the cell cycle through G(2)/M. Protein function: Ubiquitin E3 ligase that acts as a limiting factor for crossing-over during meiosis: required during zygonema to limit the colocalization of RNF212 with MutS-gamma-associated recombination sites and thereby establish early differentiation of crossover and non- crossover sites. Later, it is directed by MutL-gamma to stably accumulate at designated crossover sites. Probably promotes the dissociation of RNF212 and MutS-gamma to allow the progression of recombination and the implementation of the final steps of crossing over. Modulates cyclin-B levels and participates in the regulation of cell cycle progression through the G2 phase. Overexpression causes delayed entry into mitosis. [The UniProt Consortium]
Keywords:
C14orf18, CCNB1IP1, Human enhancer of invasion 10, Cyclin-B1-interacting protein 1, E3 ubiquitin-protein ligase CCNB1IP1, RING-type E3 ubiquitin transferase CCNB1IP1, CCNB1IP1 Polyclonal Antibody
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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