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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
AG-20T-0135-C100 | 100 µg | - |
3 - 9 business days* |
380.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon... more
Product information "Anti-Caspase-2, clone 10C6"
Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation cascade of caspases responsible for apoptosis execution. Activation occurs upon recruitment to a complex containing a p53-induced death domain protein, PIDD. This suggests caspase-2 can be a nuclear initiator caspase with a requirement for caspase-9 and caspase-3 activation in downstream apoptotic events. In apoptotic pathways resulting from UV-induced DNA damage, processing of caspase-2 occurs downstream of mitochondrial dysfunction and of caspase-9 and caspase-3 activation, extending a possible role for caspase-2 as a parallel effector caspase.
Keywords: | Anti-ICH1, Anti-CASP2, EC=3.4.22.55 |
Supplier: | AdipoGen Life Sciences |
Supplier-Nr: | AG-20T-0135 |
Properties
Application: | ELISA, FC, ICC, IHC |
Antibody Type: | Monoclonal |
Clone: | 10C6 |
Conjugate: | No |
Host: | Rat |
Species reactivity: | dog, human, monkey, mouse, rat |
Immunogen: | Recombinant human caspase-2 (p19 subunit) |
Purity: | >95% |
Format: | Purified |
Database Information
KEGG ID : | K02186 | Matching products |
UniProt ID : | P42575 | Matching products |
Gene ID | GeneID 835 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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