69 products were found matching "K02186"!

Z-VDVAD-FMK is a peptide caspase-2 inhibitor. Intravitreal injection of Z-VDVAD-FMK (4,000 ng/ml) reduces optic nerve crushing-induced retinal ganglion cell apoptosis in rats. It also prevents endothelial cell apoptosis in a dog model of subarachnoid hemorrhage-induced chronic cerebral vasospasm. InChI:...

Rabbit Polyclonal CASP2 Antibody against Human caspase 2. Validated for Western Blot. Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Interspecies information: Highest antigen sequence indentity to the following orthologs: ENSMUSG00000029863: 84%, ENSRNOG00000016707: 84%. Protein...

This kits makes use of a cell-permeant green fluorecent probe (FAM-VDVAD-FMK ) that binds to active caspase-2 in living cells undergoing apoptosis. Excitation wavelength 488-492nm, emission 515-535nm.

This kits makes use of a cell-permeant green fluorecent probe (FAM-VDVAD-FMK ) that binds to active caspase-2 in living cells undergoing apoptosis. Excitation wavelength 488-492nm, emission 515-535nm.

Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation...

Caspase-2 is a Class I caspase with a long prodomain necessary for nuclear localization. Upon activation of the apoptotic pathway, the procaspase is cleaved into smaller fragments. Caspase-2 is the nuclear apoptotic respondent to cellular genotoxic stress or mitotic catastrophe and is involved in the activation...

Protein function: Involved in the activation cascade of caspases responsible for apoptosis execution. Might function by either activating some proteins required for cell death or inactivating proteins necessary for cell survival. [The UniProt Consortium]

0.5mg/ml if reconstituted with 0.2ml sterile DI water. Caspase-2/CASP2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. Activation of Caspase-2 occurs in a complex that contains the death domain-containing protein PIDD,...

0.5mg/ml if reconstituted with 0.2ml sterile DI water. CASP2 is equal to Caspase-2. And Caspase-2, which is involved in stress-induced apoptosis, is recruited into a large protein complex, the molecular composition of which remains elusive. It is showed that activation of caspase-2 occurs in a complex that contains...

Z-VDVAD-FMK is a synthetic peptide that irreversibly inhibits the activity of caspase-2. It attenuates oxyhemoglobin-induced cleavage of PARP and apoptosis in endothelial cells. Z-VDVAD-FMK can be used for both in vitro and in vivo studies--see note for using this product in vitro.

This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Caspases mediate cellular apoptosis through the proteolytic cleavage of specific protein substrates. The encoded protein may function in stress-induced cell death pathways, cell cycle maintenance, and the suppression of...

Ac-VDVAD-pNA is a colorimetric substrate for caspase-2. Caspase-2 binds to and cleaves the Val-Asp-Val-Ala-Asp (VDVAD) peptide sequence to release p-nitroanilide (pNA), which can be quantified by colorimetric detection at 405 nm as a measure of caspase-2 activity. Ac-VDVAD-pNA can also be cleaved, with lower...