Anti-Caspase-14 (Clone: ABM1B24)

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Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Discount	Price
ABE-10-1009-25	25 µg		-		3 - 11 business days*		15 %	149.00€ 126.65€
ABE-10-1009-100	100 µg		-		3 - 11 business days*		15 %	418.00€ 355.30€

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Protein function: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant... more

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Product information "Anti-Caspase-14 (Clone: ABM1B24)"

Protein function: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin. In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis. May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736). [The UniProt Consortium]

Keywords:	Anti-CASP14, EC=3.4.22.-, Monoclonal Antibody to Caspase-14 (Clone: ABM1B24)
Supplier:	Abeomics
Supplier-Nr:	10-1009

Properties

Application:	FC
Antibody Type:	Monoclonal
Clone:	ABM1B24
Conjugate:	No
Host:	Mouse
Species reactivity:	human
Immunogen:	Full length recombinant protein of Caspase 14 was used as the immunogen for this antibody.
Format:	Purified