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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ABE-20-1066-50 | 50 µl | - |
3 - 11 business days* |
373.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Ipaf (also known as Clan/CARD12) is a CARD domain containing protein. In general CARD proteins... more
Product information "Anti-CARD12 (IPAF/ClAN)"
Ipaf (also known as Clan/CARD12) is a CARD domain containing protein. In general CARD proteins are implicated in host defense against infection, environmental stress or cellular damage. CARD domains are found in the N-terminal pro-domains of certain caspases, a family of apoptotic and pro-inflammatory proteases, as well as in a diversity of other proteins including Ipaf/Clan/CARD12. There are at least three major signaling pathways in which CARD proteins act: (1) Regulation of caspase activation in the context of apoptosis (2) Regulation of caspase activation in the context of inflammation (3) Regaultion of NF-kB activation in the context of innate or adaptive immune responses. As there is significant crosstalk between pathways that lead to caspase-mediated apoptosis or inflammation and pathways that result in NF-kB activation, it is logical that similar protein modules such as CARD domains are found repeatedly in proteins from all three pathways. Ipaf plays a role in regulating caspase-1 activity, which in turn mediates the maturation of inflammatory cytokines IL-1b and IL-18. Ipaf also interact with the pro-apoptotic adaptor protein ASC and co-expression of Ipaf with ASC has been shown to induce NF-kB activation and apoptosis. Protein function: Key component of inflammasomes that indirectly senses specific proteins from pathogenic bacteria and fungi and responds by assembling an inflammasome complex that promotes caspase-1 activation, cytokine production and macrophage pyroptosis (PubMed:15107016). The NLRC4 inflammasome is activated as part of the innate immune response to a range of intracellular bacteria. [The UniProt Consortium]
Keywords: | Anti-Ipaf, Anti-NLRC4, Anti-CARD12, Anti-Clan protein, Anti-Ice protease-activating factor, Anti-CARD, LRR, and NACHT-containing protein, Anti-NLR family CARD domain-containing protein 4, Anti-Caspase recruitment domain-containing protein 12, Polyclonal a |
Supplier: | Abeomics |
Supplier-Nr: | 20-1066 |
Properties
Application: | WB, IHC, IP |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse (Expected: rat) |
Immunogen: | A synthetic peptide of IPAF/ClAN/CARD12 (amino acis 637-654 EEAPETYIPSRAVSLFFN) was used as immunogen for this antibody |
Format: | Sera |
Database Information
KEGG ID : | K12805 | Matching products |
UniProt ID : | Q9NPP4 | Matching products |
Gene ID | GeneID 58484 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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