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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved... more
Product information "Anti-CAND1"
This gene encodes an essential regulator of Cullin-RING ubiquitin ligases, which are in involved in ubiquitinylation of proteins degraded by the Ub proteasome system. The encoded protein binds to unneddylated cullin-RING box protein complexes and acts as an inhibitor of cullin neddylation and of Skp1, cullin, and F box ubiquitin ligase complex assembly and activity. In mammalian cell culture, this protein predominantly localizes to the cytoplasm. Knockdown of this gene in preadipocytes results in blocked adipogenesis. Alternative splicing results in multiple transcript variants. Protein function: Key assembly factor of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes that promotes the exchange of the substrate- recognition F-box subunit in SCF complexes, thereby playing a key role in the cellular repertoire of SCF complexes. Acts as a F-box protein exchange factor. The exchange activity of CAND1 is coupled with cycles of neddylation conjugation: in the deneddylated state, cullin-binding CAND1 binds CUL1-RBX1, increasing dissociation of the SCF complex and promoting exchange of the F-box protein. Probably plays a similar role in other cullin-RING E3 ubiquitin ligase complexes. [The UniProt Consortium]
Keywords: | Anti-CAND1, Anti-KIAA0829, Anti-p120 CAND1, Anti-TBP-interacting protein 120A, Anti-TBP-interacting protein of 120 kDa A, Anti-Cullin-associated NEDD8-dissociated protein 1, Anti-Cullin-associated and neddylation-dissociated protein 1, CAND1 Polyclonal An |
Supplier: | Elabscience |
Supplier-Nr: | E-AB-66264 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | Recombinant fusion protein of human CAND1 (NP_060918.2). |
Database Information
KEGG ID : | K17263 | Matching products |
UniProt ID : | Q86VP6 | Matching products |
Gene ID | GeneID 55832 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | 4°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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