Anti-Calcitonin / CALCA / CGRP, clone CALCA/8639R

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V4151SAF-100UG 100 µg - -

3 - 10 business days*

752.00€
 
1 mg/ml in 1X PBS, BSA free, sodium azide free. Calcitonin is a 32 amino acid polypeptide hormone... more
Product information "Anti-Calcitonin / CALCA / CGRP, clone CALCA/8639R"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Calcitonin is a 32 amino acid polypeptide hormone that preserves skeletal integrity and reduces blood calcium levels by decreasing osteoclast activity in bones, calcium and phosphate reabsorption by kidney tubules and calcium absorption by the intestines. The secretion of Calcitonin from the thyroid is regulated in part by estrogen, which increases Calcitonin mRNA levels. The Calcitonin gene, CALCA, undergoes tissue-specific RNA alternative splicing, resulting in the production of different mRNA transcripts. One transcript encodes procalcitonin as well as both calcium-lowering processed active polypeptides, Calcitonin and katacalcin. An alternative transcript of CALCA encodes the precursor for the neuropeptide referred to as Calcitonin generelated peptide 1, also designated CGRP1 or Alpha-CGRP. CGRP is a widely distributed vasodilatory peptide. Calcitonin and katacalcin are produced primarily in the thyroid, while CGRP is produced in neuronal cells. A second CGRP related gene, CALCB, thought to be derived from an gene duplication event, has been identified in mouse, rat and human. Unlike CALCA, CALCB is not subject to alternative splicing and encodes a single transcript designated CGRP2 or Beta-CGRP. Mature CGRP1 and CGRP2 share significant sequence identity at the protein level differing by only 1-3 amino acid residues, depending on the species. Protein function: Calcitonin causes a rapid but short-lived drop in the level of calcium and phosphate in blood by promoting the incorporation of those ions in the bones. [The UniProt Consortium]
Keywords: Anti-CALC1, Anti-CALCA, Calcitonin Antibody / CALCA / CGRP
Supplier: NSJ Bioreagents
Supplier-Nr: V4151SAF

Properties

Application: IHC (paraffin)
Antibody Type: Monoclonal
Clone: CALCA/8639R
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: A recombinant fragment of human Calcitonin protein (around aa 1-141)
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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