Anti-BUB1B / BubR1

Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-RQ5566 100 µg - -

3 - 10 business days*

755.00€
 
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Mitotic checkpoint... more
Product information "Anti-BUB1B / BubR1"
0.5mg/ml if reconstituted with 0.2ml sterile DI water. Mitotic checkpoint serine/threonine-protein kinase BUB1 beta is an enzyme that in humans is encoded by the BUB1B gene. This gene encodes a kinase involved in spindle checkpoint function. The protein has been localized to the kinetochore and plays a role in the inhibition of the anaphase-promoting complex/cyclosome (APC/C), delaying the onset of anaphase and ensuring proper chromosome segregation. Impaired spindle checkpoint function has been found in many forms of cancer. Protein function: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase- promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. [The UniProt Consortium]
Keywords: Anti-BUBR1, Anti-BUB1B, Anti-hBUBR1, EC=2.7.11.1, Anti-Protein SSK1, Anti-Mitotic checkpoint kinase MAD3L, Anti-MAD3/BUB1-related protein kinase, Anti-Mitotic checkpoint serine/threonine-protein kinase BUB1 beta, BUB1B Antibody / BubR1
Supplier: NSJ Bioreagents
Supplier-Nr: RQ5566

Properties

Application: WB, IHC (paraffin), FC, IF, Direct ELISA
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: A human recombinant protein (amino acids K26-E448)
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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