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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
IHC-00715-T | 10 µl (2500 ng) | - |
2 - 8 business days* |
164.00€
|
|||
IHC-00715 | 100 µl (25 µg) | - |
2 - 8 business days* |
623.00€
|
Protein function: Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains... more
Product information "Anti-BRCC36 (IHC)"
Protein function: Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1, deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). [The UniProt Consortium]
Keywords: | Anti-BRCC3, Anti-BRCC36, Anti-BRISC complex subunit BRCC36, Anti-BRCA1-A complex subunit BRCC36, Anti-Lys-63-specific deubiquitinase BRCC36, Anti-BRCA1/BRCA2-containing complex subunit 3, Anti-BRCA1/BRCA2-containing complex subunit 36 |
Supplier: | Bethyl Laboratories |
Supplier-Nr: | IHC-00715 |
Properties
Application: | IHC |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human (Expected: horse, swine, panda, orangutan, rhesus monkey, nine-banded armadillo, white-tufted-ear marmoset, dusky titi monkey, crab-eating macaque, african elephant, little brown bat, greater horseshoe bat, northern white-cheeked gibbon) |
Immunogen: | synthetic peptide |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K11864 | Matching products |
UniProt ID : | P46736 | Matching products |
Gene ID | GeneID 79184 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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