Anti-BRCC36

Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-401-Z89 100 µg - -

6 - 10 business days*

684.00€
 
Anti-BRCC36 Antibody was affinity purified from monospecific antiserum by immunoaffinity... more
Product information "Anti-BRCC36"
Anti-BRCC36 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography. Cross reactivity with BRCC36 from other sources has not been determined. Protein function: Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains. Does not have activity toward 'Lys- 48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'- specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. [The UniProt Consortium]
Keywords: Anti-BRCC3, Anti-BRCC36, EC=3.4.19.-, Anti-BRISC complex subunit BRCC36, Anti-BRCA1-A complex subunit BRCC36, Anti-Lys-63-specific deubiquitinase BRCC36, Anti-BRCA1/BRCA2-containing complex subunit 3, Anti-BRCA1/BRCA2-containing complex subunit 36
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-401-Z89

Properties

Application: ELISA, IHC, IFM, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: 18 amino acid synthetic peptide from near the N-terminus of human BRCC36.
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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