Anti-BRCC36

Anti-BRCC36
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A302-517A-T 20 µl (2 blots) -

3 - 9 business days*

131.00€
A302-517A-M 100 µl (10 blots) -

3 - 9 business days*

313.00€
A302-517A 100 µl (100 µg) -

3 - 9 business days*

465.00€
 
Protein function: Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains... more
Product information "Anti-BRCC36"
Protein function: Metalloprotease that specifically cleaves 'Lys-63'- linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double- strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1, deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). [The UniProt Consortium]
Keywords: Anti-BRCC3, Anti-BRCC36, Anti-BRISC complex subunit BRCC36, Anti-BRCA1-A complex subunit BRCC36, Anti-Lys-63-specific deubiquitinase BRCC36, Anti-BRCA1/BRCA2-containing complex subunit 3, Anti-BRCA1/BRCA2-containing complex subunit 36
Supplier: Bethyl Laboratories
Supplier-Nr: A302-517A

Properties

Application: WB, IP, IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse (Expected: Orangutan)
Immunogen: synthetic peptide. The epitope recognized by A302-517A-T maps to a region between residue 266 and 316 of human BRCA1/BRCA2-containing complex subunit 36 using the numbering given in entry NP_077308.1 (GeneID 79184).
Format: Antigen Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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