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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V4594-20UG | 20 µg | - | - |
3 - 10 business days* |
332.00€
|
||
NSJ-V4594-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. The BRAF gene encodes a... more
Product information "Anti-BRAF, clone BRAF/1323"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide. The BRAF gene encodes a cytoplasmic serine-threonine kinase, which initiates the activation of the mitogen-activated protein kinase (MAPK) signalling pathway. The oncogenic mutations in the kinase region of BRAF gene result in constitutive activation of the MAPK signalling pathway, leading to increased cell proliferation, resistance to apoptosis and tumor progression. The most common of all activating BRAF mutations leads to a substitution of valine (V) to glutamic acid (E) at the position 600 of the amino acid sequence. The BRAF V600E mutation is an important predictive and prognostic biomarker. The BRAF V600E mutation is detected in approximately 8% of all solid tumours, including 45% of papillary thyroid carcinomas, 40-60% of melanomas, 5-15% of colorectal adenocarcinomas, 35% of serous low grade and borderline ovarian carcinomas, 1-3% of non-small cell lung cancers, and 5-7% of cholangiocarcinomas. Furthermore, the BRAF V600E mutation is found in 100% of hairy cell leukaemia, 54% Erdheim-Chester disease, 38% of Langerhans cell histocytoses and 60% of pleomorphic xanthoastrocytomas. Protein function: Required for correct progression through G2 phase of the cell cycle and entry into mitosis. Required for RCOR1/CoREST mediated repression of neuronal specific gene promoters. [The UniProt Consortium]
Keywords: | Anti-BRAF35, Anti-HMG20B, Anti-SMARCE1-related protein, Anti-BRCA2-associated factor 35, Anti-HMG box-containing protein 20B, Anti-Sox-like transcriptional factor, Anti-HMG domain-containing protein 2, Anti-HMG domain-containing protein HMGX2, BRAF Antibo |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V4594 |
Properties
Application: | IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | BRAF/1323 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | A recombinant fragment of human HMG20B protein |
Format: | Purified |
Database Information
KEGG ID : | K24650 | Matching products |
UniProt ID : | Q9P0W2 | Matching products |
Gene ID | GeneID 10362 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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