Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A2275-87J.50 | 50 µg | - | - |
3 - 19 business days* |
848.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Senile plaques and neurofibrillary tangles in brain are hallmarks of Alzheimer's disease.... more
Product information "Anti-beta-Amyloid Precursor Protein (APP)"
Senile plaques and neurofibrillary tangles in brain are hallmarks of Alzheimer's disease. Mutations in the beta-amyloid precursor protein (beta-APP) are contributory factors to Familial Alzheimer's Disease. The primary constituent of senile plaques are deposits of the 4 kD amyloid beta-peptide, derived from amyloid beta-precursor proteins by internal proteolysis. The major brain beta-APP isoforms (APP695, 751, 770) are integral membrane proteins with a single large N-terminal extracellular domain, a single transmembrane domain, and a small cytoplasmic C-terminal tail. In the early 1990s, it was discovered that beta-APP is a useful marker for axonal injury. beta-APP is carried by fast anterograde transport vesicles to distal sites in the axon with the beta-APP C-terminus residing in the cytoplasm and the N-terminus in the vesicle. Upon axonal injury, beta-APP will pool in areas of impaired transport. beta-APP has been used as a marker of axonal injury in many studies of different pathologies, including: head trauma, HTLV-I-associated myelopathy, multiple sclerosis, shaken baby syndrome, and encephalomyelitis among others. Applications: Suitable for use in ELISA, Western Blot, Immunofluorscence and Immunoprecipitation. Other applications have not been tested. Recommended Dilution: ELISA: 0.1-1ug/ml, Western Blot: 0.2-2ug/ml, Immunofluoresence: 1-5ug/ml, Immunohistochemistry: 0.1-1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Supplier: | United States Biological |
Supplier-Nr: | A2275-87J |
Properties
Application: | ELISA, IF, IP, WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Format: | Affinity Purified |
Database Information
Handling & Safety
Storage: | -20°C (frozen cool packs) |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed