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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
B0003-05N2.100 | 100 µg | - | - |
3 - 19 business days* |
644.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus... more
Product information "Anti-Bacillus anthracis (Anthrax) PA (Protective Antigen) Protein"
Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF) (1,2 for review). PA binds to two related proteins on the cell surface, these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) (3) and capillary morphogenesis protein 2 (CMG2) (4), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF, the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm (5). These toxins are usually sufficient to cause rapid cell death, and often the death of the organism. Applications: Suitable for use in ELISA. Other applications have not been tested. Recommended Dilution: ELISA: 1ug/ml will detect 10ng free peptide of PA protein., Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, add sterile glycerol (40-50%), aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-pag, Anti-PA63, Anti-PA20, Anti-PA83, Anti-pagA, Anti-PA-83, Anti-Protective antigen, Anti-Protective antigen PA-20, Anti-Protective antigen PA-63, Anti-Anthrax toxins translocating protein |
Supplier: | United States Biological |
Supplier-Nr: | B0003-05N2 |
Properties
Application: | ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Format: | Affinity Purified |
Database Information
KEGG ID : | K11030 | Matching products |
UniProt ID : | P13423 | Matching products |
Gene ID | GeneID 1158723 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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