Anti-BACE1 (46-65) (Beta-site APP Cleaving Enzyme)

Anti-BACE1 (46-65) (Beta-site APP Cleaving Enzyme)
Item number Size Datasheet Manual SDS Delivery time Quantity Price
B0002-91B1.40 40 µg - -

3 - 19 business days

346.00€
 
b-secretase, also called BACE (b-site of APP cleaving enzyme), is an aspartic-acid protease... more
Product information "Anti-BACE1 (46-65) (Beta-site APP Cleaving Enzyme)"
b-secretase, also called BACE (b-site of APP cleaving enzyme), is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease and in the formation of myelin sheaths in peripheral nerve cells. BACE1, also known as memapsin-2, is the major b-secretase for generation of the 40 or 42 amino-acid-long b-amyloid peptides that aggregate in the brains of Alzheimer's patients. Extracellular cleavage of APP by BACE1 releases a soluble extracellular fragment and is followed by APP cleavage within its transmembrane domain by gamma-secretase. The second cleavage releases the intracellular domain of APP and b-amyloid. The immature form of BACE1 contains an N-terminal signal sequence (residues 1-21) followed by a large catalytic domain, a single transmembrane domain (residues 461-477), and a short cytoplasmic domain (residues 478-501). The signal sequence (1-21) is cleaved from the immature form, yielding the proBACE1 protein which starts at residue 22. The proBACE1 protein is modified by cleavage of 12 N-terminal residues (aa 22-45), producing the mature BACE1 protein. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 0.05-0.2ug/ml, Western Blot: 0.1-1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.er.
Supplier: United States Biological
Supplier-Nr: B0002-91B1

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human
Immunogen: Synthetic peptide [ETDEEPEEPGRRGSFVEMVD], corresponding to amino acids 46-65 of human BACE1. (KLH-conjugated)
Purity: Purified by immunoaffinity chromatography.
Format: Affinity Purified

Database Information

Handling & Safety

Storage: -20°C (-20°C Glycerol)
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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