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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A4159-04A-Biotin.200 | 200 µl | - | - |
3 - 19 business days* |
993.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative... more
Product information "Anti-ATXN1 (S776) (Ataxin-1, Spinocerebellar Ataxia Type 1 Protein, ATX1, SCA1) (Azide Free) (Biotin"
The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations. The function of the ataxins is not known. Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:1,000, Western Blot: 1:50-1:100, Optimal dilutions to be determined by the researcher. Storage and Stability: Store product at 4°C if to be used immediately within two weeks. For long-term storage, aliquot to avoid repeated freezing and thawing and store at -20°C. Aliquots are stable at -20°C for 12 months after receipt. Dilute required amount only prior to immediate use. Further dilutions can be made in assay buffer. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. , , Note: Applications are based on unconjugated antibody.
Keywords: | Anti-ATX1, Anti-ATXN1, Anti-Ataxin-1, Anti-Spinocerebellar ataxia type 1 protein |
Supplier: | United States Biological |
Supplier-Nr: | A4159-04A-Biotin |
Properties
Application: | ELISA, WB |
Antibody Type: | Polyclonal |
Conjugate: | Biotin |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | Synthetic peptide corresponding to amino acid residues surrounding S776 of human ATXN1 (KLH). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K23616 | Matching products |
UniProt ID : | P54253 | Matching products |
Gene ID | GeneID 6310 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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