Anti-ATR

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG54457.50	50 µg		-	-	6 - 14 business days*		608.00€

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Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon... more

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Product information "Anti-ATR"

Protein function: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication. [The UniProt Consortium]

Keywords:	Anti-ATR, Anti-FRP1, EC=2.7.11.1, Anti-FRAP-related protein 1, Anti-Serine/threonine-protein kinase ATR, Anti-Ataxia telangiectasia and Rad3-related protein
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG54457

Properties

Application:	WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	Synthetic peptide representing a portion of the protein encoded within exon 5 (LocusLink ID 545)