Anti-ATIC

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ATA-HPA021012.25	25 µl		-		7 - 10 business days*		335.00€
ATA-HPA021012.100	100 µl		-		7 - 10 business days*		446.00€

If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk

Protein function: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis... more

Close menu

Product information "Anti-ATIC"

Protein function: Bifunctional enzyme that catalyzes the last two steps of purine biosynthesis (PubMed:11948179, PubMed:14756554). Acts as a transformylase that incorporates a formyl group to the AMP analog AICAR (5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) to produce the intermediate formyl-AICAR (FAICAR) (PubMed:9378707, PubMed:11948179, PubMed:10985775). Can use both 10-formyldihydrofolate and 10-formyltetrahydrofolate as the formyl donor in this reaction (PubMed:10985775). Also catalyzes the cyclization of FAICAR to IMP (PubMed:11948179, PubMed:14756554). Is able to convert thio-AICAR to 6- mercaptopurine ribonucleotide, an inhibitor of purine biosynthesis used in the treatment of human leukemias (PubMed:10985775). Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). [The UniProt Consortium] Buffer: 40% glycerol and PBS (pH 7.2). 0.02% sodium azide is added as preservative. Highest antigen sequence identity to mouse: 89% and to rat: 89%

Keywords:	Anti-PURH
Supplier:	Atlas Antibodies
Supplier-Nr:	HPA021012

Properties

Application:	ICC, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse, rat
Immunogen:	Recombinant Protein Epitope Signature Tag (PrEST) antigen sequence: ANYWWLRHHP QVLSMKFKTG VKRAEISNAI DQYVTGTIGE DEDLIKWKAL FEEVPELLTE AEKKEWVEKL TEVSISSDAF FPFRDNVDRA KRSGVAYIAA PSGSAADKVV IEACDELGII LAH (ATA-APrEST74806)