Anti-ATG5

Item number Size Datasheet Manual SDS Delivery time Quantity Price
ELK-EA350.100 100 µl - -

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283.00€
 
Autophagy is generally activated by conditions of nutrient deprivation but has also been... more
Product information "Anti-ATG5"
Autophagy is generally activated by conditions of nutrient deprivation but has also been associated with a number of physiological processes including development, differentiation, neurodegeneration, infection, and cancer. Formation of the autophagosome involves a ubiquitin-like conjugation system in which Atg12 is covalently bound to Atg5 and targeted to autophagosome vesicles. This conjugation reaction is mediated by the ubiquitin E1-like enzyme Atg7 and the E2-like enzyme Atg10. Protein function: Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3- like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway. [The UniProt Consortium] Recommended dilutions: IHC 1:100-200. Cellular localization: Cytoplasm, Membrane
Keywords: Anti-ATG5, Anti-APG5L, Anti-APG5-like, Anti-Autophagy protein 5, Anti-Apoptosis-specific protein, ATG5 Rabbit pAb
Supplier: ELK Biotechnology
Supplier-Nr: EA350

Properties

Application: IHC
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human
Immunogen: Recombinant Protein
MW: 32 kD
Format: Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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