Cookie preferences
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the comfort when using this website, are used for direct advertising or to facilitate interaction with other websites and social networks, are only set with your consent.
Configuration
Technically required
These cookies are necessary for the basic functions of the shop.
"Allow all cookies" cookie
"Decline all cookies" cookie
CSRF token
Cookie preferences
Currency change
Customer-specific caching
FACT-Finder tracking
Individual prices
Selected shop
Session
Comfort functions
These cookies are used to make the shopping experience even more appealing, for example for the recognition of the visitor.
Note
Show the facebook fanpage in the right blod sidebar
Statistics & Tracking
Affiliate program
Conversion and usertracking via Google Tag Manager
Track device being used
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG22245.50 | 50 µg | - | - |
6 - 14 business days* |
520.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: Proton-gated sodium channel, it is activated by a drop of the extracellular pH... more
Product information "Anti-ASIC1, clone S271-44"
Protein function: Proton-gated sodium channel, it is activated by a drop of the extracellular pH and then becomes rapidly desensitized. Generates a biphasic current with a fast inactivating and a slow sustained phase. Has high selectivity for sodium ions and can also transport lithium ions with high efficiency. Can also transport potassium ions, but with lower efficiency. It is nearly impermeable to the larger rubidium and cesium ions. Mediates glutamate-independent Ca(2+) entry into neurons upon acidosis. This Ca(2+) overloading is toxic for cortical neurons and may be in part responsible for ischemic brain injury. Heteromeric channel assembly seems to modulate channel properties. Functions as a postsynaptic proton receptor that influences intracellular Ca(2+) concentration and calmodulin-dependent protein kinase II phosphorylation and thereby the density of dendritic spines. Modulates activity in the circuits underlying innate fear. [The UniProt Consortium]
Keywords: | Anti-ASIC1, Anti-BNaC2, Anti-Asic1, Anti-Accn2, Anti-Brain sodium channel 2, Anti-Acid-sensing ion channel, Anti-Acid-sensing ion channel 1, Anti-Amiloride-sensitive cation channel 2, neuronal |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG22245 |
Properties
Application: | WB, IHC, ICC, IF |
Antibody Type: | Monoclonal |
Clone: | S271-44 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | mouse, rat |
Immunogen: | Fusion protein amino acids 460-526 (Cytoplasmic C-terminus) of Mouse ASIC1 |
MW: | 60 kD |
Format: | Purified |
Database Information
KEGG ID : | K04829 | Matching products |
UniProt ID : | Q6NXK8 | Matching products |
Gene ID | GeneID 11419 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
more
You will get a certificate here
Viewed