Anti-Apolipoprotein J (Apo J)

Anti-Apolipoprotein J (Apo J)
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*1 Offer expires 31/03/2021
Item number Size Datasheet Manual SDS Delivery time Quantity Price
600-101-198 500 µg - -

3 - 9 business days*

579.00€
 
Protein function: Isoform 1 functions as extracellular chaperone that prevents aggregation of... more
Product information "Anti-Apolipoprotein J (Apo J)"
Protein function: Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress- induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional activity. Nuclear isoforms promote apoptosis. Mitochondrial isoforms suppress BAX-dependent release of cytochrome c into the cytoplasm and inhibit apoptosis. Plays a role in the regulation of cell proliferation. [The UniProt Consortium]
Keywords: Anti-CLU, Anti-APOJ, Anti-AAG4
Supplier: Rockland Immunochemicals
Supplier-Nr: 600-101-198

Properties

Application: ELISA, IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Reactivity: Human
Immunogen: apolipoprotein J [human plasma]
Format: Affinity Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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