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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A2298-79H4.100 | 100 µg | - | - |
3 - 19 business days* |
581.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified... more
Product information "Anti-APIP (Probable Methylthioribulose-1-phosphate Dehydratase, MTRu-1-P Dehydratase, APAF1-interact"
The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis protease-activating factor 1) (1,2). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3 that is one of the key proteases, being responsible for the proteolytic cleavage of many key proteins in apoptosis3. Recently, Cho et al (4) have identified a new Apaf-1 Interactiong Protein (APIP) also known as CG129 and MMRP19, as a negative regulator of ischemic injury. APIP competes with Caspase-9 binding site of Apaf1. APIP is predicted to code for a 204aa. An isoform of APIP, APIP2 encodes a 242aa protein, which is an alternative splicing variant differing in its N-terminus from APIP. APIP transcript is ubiquitously expressed in most adult tissue with high expression in skeletal muscle, heart, and kidney. Applications: Suitable for use in Western Blot. Other applications not tested. Recommended Dilution: Western Blot: 1-2ug/ml, Optimal dilutions to be determined by the researcher. Positive Control: HeLa or 293, Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: | EC=4.2.1.109, Anti-MTRu-1-P dehydratase, Anti-APAF1-interacting protein, Anti-Probable methylthioribulose-1-phosphate dehydratase |
Supplier: | United States Biological |
Supplier-Nr: | A2298-79H4 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | 11E19 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Full-length his-tagged recombinant corresponding to APIP protein. |
Format: | Affinity Purified |
Database Information
KEGG ID : | K08964 | Matching products |
UniProt ID : | Q96GX9 | Matching products |
Gene ID | GeneID 51074 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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