Anti-AP3 Delta

AP3D1 (AP-3 complex subunit delta-1) encodes the delta 1 subunit of an adaptor protein regulating intracellular vesicle-mediated transport (19631730). Lack of expression of functional AP-3, leads to a deficiency in vesicle transport and storage, which affects neurotransmitter vesicle turnover and release in the central nervous system (19032734). The AP-3 complex facilitates the budding of vesicles from the golgi membrane, and directly involved in trafficking to lysosomes. It is implicated in intracellular biogenesis and trafficking of pigment granules and possibly platelet dense granules and neurotransmitter vesicles. Protein function: Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. Involved in process of CD8+ T-cell and NK cell degranulation (PubMed:26744459). In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. [The UniProt Consortium]