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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
A2293-48U.500 | 500 µg | - | - |
3 - 19 business days* |
1,174.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Human Angiopoietin4(Ang4) (1), alternatively named Ang3 (2), is a secreted glycoprotein belonging... more
Product information "Anti-ANGPTL4 (Angiopoietin-related Protein 4, Angiopoietin-like Protein 4, Hepatic Fibrinogen/Angiop"
Human Angiopoietin4(Ang4) (1), alternatively named Ang3 (2), is a secreted glycoprotein belonging to the angiopoietin family. It has the characteristic structuralmotifs of angiopoietins including the coiledcoileddomain near the aminoterminusand a fibrinogen like domain at the Cterminus. Human Ang 4 cDNA encodes a 503aa precursor protein with a 23aa signal peptide. It shares 45%, 47% and 54% aa sequence identity with human Ang1, human Ang2 and mouse Ang3, respectively. Although the sequence homology is much higher between the human and mouse counterparts for Ang1(97%) and Ang2 (85%), mouse Ang3 is believed to be an ortholog of human Ang4 based on chromosomal localization studies (2). Human Ang4, is highly expressed in lung and in cultured human umbilical vein endothelial cells (HUVECs). In contrast, mouse Ang3 is expressed multiple mouse tissues. Human Ang4 is an agonist that can bind and activate Tie2, a receptor tyrosine kinase with immunoglobulin and epidermal growth factor homology domains expressed primarily on endothelial cells and early hematopoietic cells (2,3). Mouse Ang3 has been reported to be a Tie2 antagonist. It is likely that mouse Ang3, like Ang2, may exert agonist or antagonist activities depending on the cell content(1,3,4). Applications: Suitable for use in ELISA. Other applications not tested. Recommended Dilution: ELISA: 0.10.4ug/ml , Optimal dilutions to be determined by the researcher. Storage and Stability: Lyophilized powder may be stored at -20°C. Stable for 12 months at -20°C. Reconstitute with sterile PBS. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Reconstituted product is stable for 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: | Anti-ANGPT4 |
Supplier: | United States Biological |
Supplier-Nr: | A2293-48U |
Properties
Application: | ELISA |
Antibody Type: | Monoclonal |
Clone: | 11D57 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant corresponding to human Angiopoietin4 expressed in NSO cells (Q9Y264). |
Format: | Affinity Purified |
Database Information
KEGG ID : | K05467 | Matching products |
UniProt ID : | Q9Y264 | Matching products |
Gene ID | GeneID 51378 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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