Anti-Angiotensin II Type 1 Receptor (AGTR1, Angiotensin II Receptor, Type 1, AG2S, AGTR1A, AGTR1B, A

Anti-Angiotensin II Type 1 Receptor (AGTR1, Angiotensin II Receptor, Type 1, AG2S, AGTR1A, AGTR1B, A
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A2295-07B.100 100 µg - -

3 - 19 business days*

725.00€
 
Angiotensin II interacts with two types of G-protein coupled membrane receptors, AT1 (type 1) and... more
Product information "Anti-Angiotensin II Type 1 Receptor (AGTR1, Angiotensin II Receptor, Type 1, AG2S, AGTR1A, AGTR1B, A"
Angiotensin II interacts with two types of G-protein coupled membrane receptors, AT1 (type 1) and AT2 (type 2). Major cardiovascular effects appear to be mediated through AT1. AT1 has three isoforms (rat AT1A 359aa, AT1B/AT III, 359aa, and AT1C, 177aa). Rat AT1 receptors are predicted to contain seven transmembrane domains. The N-terminus is predicted to be extracellular. The C-terminus is inside the membrane (cytoplasmic). The binding of angiotensin II with AT1 receptors activate a phosphatidylinositol-calcium second messenger system. AT1 receptors are expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscle. AT2 gene ( chromosome x) encodes 363 aa protein. It is highly expressed in myometrium with lower levels in adrenal and fallopian tube. It is also expressed at high levels in fetal kidney and intestine. Rat AT1 receptors are predicted to contain seven transmembrane domains. The N-terminus is predicted to be extracellular, while C-terminus inside the membrane (cytoplasmic). The binding of angiotensin II with AT1 receptors activate a phosphatidylinositol-calcium second messenger system. AT1 receptors are expressed in the liver, kidney, aorta, lung, uterus, ovary, spleen, heart, adrenal and vascular smooth muscle. AT2 gene (chromosome x) encodes 363aa protein. It is expressed at high levels in myometrium, fetal kidney and intestine. It is expressed at lower levels in adrenal and fallopian tube. , All reported variants represent identical protein (NP_000676.1, NP_004826.2, NP_033611.1, NP_114038.1 and NP_114438.1). Applications: Suitable for use in ELISA and Western Blot. Other applications not tested. Recommended Dilution: ELISA: 1:32000, Western Blot: 0.3-1ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. For long-term storage and to avoid repeated freezing and thawing, aliquot and store at -20°C. Aliquots are stable for at least 12 months at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.
Keywords: Anti-AT1AR, Anti-AT1BR, Anti-Angiotensin II type-1 receptor, Anti-Type-1 angiotensin II receptor
Supplier: United States Biological
Supplier-Nr: A2295-07B

Properties

Application: ELISA, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Goat
Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide of AGTR1.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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