72 products were found matching "K04166"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse AGTR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse AGTR1. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human AGTR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human AGTR1. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat AGTR1. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat AGTR1. Next,...

Losartan is an antagonist of angiotensin II type 1b (AT1b) receptor (IC50 = 2.2 nM in COS-7 cells expressing the rat receptor). It reduces U-46619-induced aggregation of platelets in isolated human platelet-rich plasma when used at a concentration of 5 µM. It decreases 1-lipoxygenase (1-LO) levels in the endothelial...

Angiotensin II is a peptide hormone which regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure. Valsartan is a nonpeptide angiotensin II receptor antagonist of the angiotensin II type 1 (AT1) receptor (IC50 =...

Fimasartan is an antagonist of the angiotensin II type 1 (AT1) receptor (IC50 = 0.16 nM in HEK293 cells expressing the human receptor). It is selective for the AT1- over the AT2 receptor (IC50 = 69 µM). Fimasartan (62.5, 125, and 250 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS) levels...

Angiotensin II is a peptide hormone which regulates blood pressure and fluid balance, contributing to hypertension, atherosclerosis, left ventricular hypertrophy, myocardial infarction, and heart failure. Telmisartan is a nonpeptide angiotensin II receptor antagonist which selectively and insurmountably inhibits the...

Candesartan cilexetil is a prodrug form of the angiotensin II type 1 receptor (AT1) antagonist candesartan (Cay-9003239). Candesartan cilexetil is converted to candesartan by hydrolysis in the gastrointestinal tract. It inhibits the pressor response induced by angiotensin II in normotensive rats (ID50 = 0.069...

Olmesartan is a non-peptide angiotensin II receptor 1 (AT1) antagonist (IC50 = 0.0077 µM for the bovine adrenal cortex receptor) and an active metabolite of olmesartan medoxomil (Cay-11614). It is formed from olmesartan medoxomil by paraoxonase 1 (PON1) in human plasma. Olmesartan is selective for AT1 over AT2 (IC50...

Losartan carboxylic acid is an antagonist of the angiotensin II type 1b (AT1b) receptor (Ki = 0.67 nM in COS-7 cells expressing the human receptor) and an active metabolite of losartan (Cay-10006594). It is formed from losartan by the cytochrome P450 (CYP) isoform CYP2C9. Losartan carboxylic acid is selective for...

Losartan-d4 is intended for use as an internal standard for the quantification of losartan (potassium salt) (Cay-10006594) by GC- or LC-MS. Losartan is an antagonist of the angiotensin (AT) II receptor subtype AT1 with a Ki value of 5-20 nM. It has an attenuating effect on vein graft atherosclerosis in rabbits and...

Telmisartan-d3 is intended for use as an internal standard for the quantification of telmisartan (Cay-11615) by GC- or LC-MS. Telmisartan is a nonpeptide angiotensin (AT) II receptor antagonist which selectively and insurmountably inhibits the AT II receptor subtype AT1 (Ki = 3.7 nM). It also acts as a partial...