Anti-Amyloid Oligomers (A11)

Item number Size Datasheet Manual SDS Delivery time Quantity Price
200-401-E88 100 µl - -

3 - 9 business days*

Anti-Amyloid Oligomers (A11) Antibody was purified by Protein A chromatography. A BLAST analysis... more
Product information "Anti-Amyloid Oligomers (A11)"
Anti-Amyloid Oligomers (A11) Antibody was purified by Protein A chromatography. A BLAST analysis was used to suggest cross-reactivity with Amyloid Oligomers (A11) from Eukaryotes, Human, Mouse, and Rat based on 100% homology with the immunizing sequence. Recognizes all types of amyloid oligomers. Appears to recognize a peptide backbone epitope that is common to amyloid oligomers, but is not found in native proteins, amyloidogenic monomer or mature amyloid fibrils. Cross-reactivity with Amyloid Oligomers (A11) from other sources has not been determined. Neuroscience research. Protein function: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis-inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER- dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]
Keywords: Anti-A4, Anti-APP
Supplier: Rockland Immunochemicals
Supplier-Nr: 200-401-E88


Application: ELISA, IHC, IFM, IP, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Reactivity: Human, Mouse, Rat
Immunogen: synthetic molecular mimic of soluble oligomers.
Format: Purified

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Our products are for laboratory research use only: Not for administration to humans!
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