267 products were found matching "K04520"!

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Rat APP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Rat APP. Next, Avidin...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Mouse APP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Mouse APP. Next,...

The test principle applied in this kit is Sandwich enzyme immunoassay. The microtiter plate provided in this kit has been pre-coated with an antibody specific to Human APP. Standards or samples are added to the appropriate microtiter plate wells then with a biotin-conjugated antibody specific to Human APP. Next,...

Ezeprogind is an inhibitor of amyloid precursor protein (APP) proteolysis. It reduces the proteolysis of full-length APP to Abeta1-38 (IC50 = 5 µM) and Abeta1-40 (IC50 = 2 µM) in SH-SY5Y cells expressing APP. Ezeprogind induces APP intracellular domain (AICD) expression at a doubling (C2) value of 0.8 µM without...

Amyloid-beta (1-42) (Abeta42) is a neurotoxic 42-amino acid protein fragment found in amyloid plaques in postmortem cerebral cortex from patients with Alzheimer's disease. Aggregation of Abeta42 results in the formation of neurotoxic fibrils or globular oligomers. Abeta42 accumulates in the brain of many transgenic...

NIAD-4 is a fluorescent probe that crosses the blood-brain barrier to bind with high affinity to amyloid-beta (Abeta) plaques (Ki = 10 nM). It displays excitation/emission spectra of 475/625 nm, respectively, with the far-red emission occurring upon binding to Abeta.Formal Name:...

Amyloid plaques composed primarily of the 42 amino acid form of amyloid-beta peptide (Abeta42) are a hallmark of Alzheimer's disease (AD). However, the roles of the various amyloid beta peptide(s), especially Abeta42, related to the neurotoxicity characteristic of AD remains unclear. A major hindrance to evaluating...

(R,S)-Anatabine is an alkaloid that has been found as a minor component in tobacco (Nicotiana). It is an agonist of alpha4beta2 and alpha6/alpha3beta2beta4 subunit-containing nicotinic acetylcholine receptors (nAChRs, EC50s = 6.1 and 3.6 µM, respectively). It is selective for alpha4beta2 and alpha6/alpha3beta2beta4...

gamma-Secretase is a multimeric aspartyl protease that regulates signaling pathways by proteolytically cleaving substrates, abrogating or releasing signaling molecules. Two well-known substrates are the carboxyl-terminal fragments (CTFs) of the receptor Notch, which has key roles in development, and that of amyloid...

Methoxy-X04 is a brain-permeable fluorescent probe for amyloid-beta (Abeta) to detect and quantify plaques, tangles, and cerebrovascular amyloid. It displays high in vitro binding affinity (Ki = 26.8 nM) for fibrillar beta-sheet deposits and is used to image Abeta plaques in the brains of living APP/PS1 mice, a...

Thioflavin T is a fluorescent probe for amyloid fibrils. It displays excitation/emission maxima of 385/445 nm, respectively, and exhibits an increase in fluorescence intensity and a shift in excitation/emission maxima to 450/482 nm upon binding to amyloid fibrils. The fluorescence intensity is also pH dependent,...

Anti-Amyloid Oligomers (A11) Antibody was purified by Protein A chromatography. A BLAST analysis was used to suggest cross-reactivity with Amyloid Oligomers (A11) from Eukaryotes, Human, Mouse, and Rat based on 100% homology with the immunizing sequence. Recognizes all types of amyloid oligomers. Appears to...