Anti-AMPK alpha-1 (human), Rabbit Monoclonal (RM301)

Recombinant Antibody. This antibody reacts to human AMPK alpha-1 (AMPKA1) (5'-AMP-activated protein kinase catalytic subunit alpha-1). Applications: WB, IHC. Source: Rabbit. Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide. AMP-activated protein kinase (AMPK) is a heterotrimeric complex consisting of a catalytic alpha subunit and regulatory beta and gamma subunits. Each subunit exists as alternate isoforms ( alpha 1, alpha 2, beta 1, beta 2, gamma 1, gamma 2, gamma 3), with all 12 combinations able to form complexes. The catalytic alpha subunit of AMPK is activated allosterically by AMP, and by phosphorylation via the AMPK kinases LKB1 and CaMKK beta. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. AMPK's role in metabolic regulation has implicated this serine/threonine kinase as a therapeutic target in heart disease, obesity and diabetes. 5'-AMP-activated protein kinase catalytic subunit alpha-1 (AMPK alpha 1) belongs to the serine/threonine protein kinase family and is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK).