235 products were found matching "K07198"!

Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces...

The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular...

AMPK alpha is the catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits...

AICAR is an activator of AMP-activated protein kinase (AMPK). It increases AMPK kinase activity in isolated hepatocytes (EC50 = ~500 µM) and reduces HMG-CoA reductase activity and fatty acid and sterol synthesis in these cells. AICAR (0.5 mM) inhibits insulin-stimulated glucose uptake to 62% of control cells and...

YW2065 is an inhibitor of Wnt/beta-catenin signaling and an activator of AMP-activated protein kinase (AMPK). It induces degradation of beta-catenin and increases the levels of Axin1 and phosphorylated AMPK and acetyl-CoA carboxylase (ACC), which is a downstream substrate of AMPK, in SW620 colorectal cancer cells...

Dorsomorphin is a potent, reversible inhibitor of AMPK (Ki = 109 nM) that does not exhibit significant activity on structurally related kinases, including ZAPK, SYK, PKCtheta, PKA, and JAK3. Dorsomorphin can also dose-dependently inhibit the bone morphogenetic protein type 1 receptors ACTR-I (ALK2), BMPR-IA (ALK3),...

A-769662 is a small molecule thienopyridone that activates AMPK directly in cell-free assays (EC50 = 116 nM) and intact cells by allosterically activating AMPK and inhibiting its dephosphorylation on Thr172. A-769662 specifically activates beta1 subunit-containing AMPK heterotrimers, and its effects are independent...

HPH-15 is an antifibrotic compound and AMPK activator. It inhibits TGF-beta1-induced collagen, fibronectin 1, and connective tissue growth factor (CTGF) production in primary human dermal fibroblasts when used at a concentration of 3 µM. HPH-15 (10 µM) increases AMPK activation, glucose uptake, and membrane...

Cordycepin is a nucleoside analog originally isolated from C. militaris that has diverse biological activities. Upon entry into cells, it is converted to cordycepin triphosphate, which inhibits ATP-dependent DNA and RNA synthesis. It incorporates into DNA and RNA at internal and terminal positions in SK-HEP-1 cells....

Metformin-d6 is intended for use as an internal standard for the quantification of metformin (Cay-13118) by GC- or LC-MS. Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent...

Soluble in water (9 mg/ml), DMSO or dimethyl formamide. Cell permeable AMP-activated protein kinase (AMPK) activator. Insulin mimetic. Adipocyte differentiation inhibitor. Apoptosis inducer. PPARalpha inhibitor. mTOR inhibitor. P70S6K inhibitor. LPS-induced TNF-alpha production inhibitor. TORC2...

AMPK activator.