Anti-Alpha Catenin, clone 1G5

Anti-Alpha Catenin, clone 1G5
Item number Size Datasheet Manual SDS Delivery time Quantity Price
NSJ-V3202-20UG 20 µg - -

3 - 10 business days

251.00€
NSJ-V3202-100UG 100 µg - -

3 - 10 business days

541.00€
 
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. Recognizes a protein... more
Product information "Anti-Alpha Catenin, clone 1G5"
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced) and 0.05% sodium azide. Recognizes a protein of 102kDa, identified as Catenin, alpha-1. Catenins comprise a large family of Ca2+-dependent, homotypic cell-cell adhesion molecules that play important roles in development, epithelial cell polarity and tumor progression. Alpha-Catenin is a key regulator of actin dynamics in cell-cell adhesion. During cell-cell adhesion, alpha-Catenin forms a heterodimer with beta-Catenin and links the cadherins to actin associated with the cytoskeleton. Alpha-Catenin also regulates the beta-Catenin signaling in various cells. It displays the tumor suppressor activity and is found to be down regulated in some forms of breast cancer. Protein function: Associates with the cytoplasmic domain of a variety of cadherins. The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties. Can associate with both E- and N-cadherins. Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions. In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherens junctions components. The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments. May play a crucial role in cell differentiation. [The UniProt Consortium]
Keywords: Anti-CTNNA1, Anti-Catenin alpha-1, Anti-Alpha E-catenin, Anti-Cadherin-associated protein, Anti-Renal carcinoma antigen NY-REN-13, Alpha Catenin Antibody
Supplier: NSJ Bioreagents
Supplier-Nr: V3202-20UG

Properties

Application: FC, IF, WB
Antibody Type: Monoclonal
Clone: 1G5
Conjugate: No
Host: Mouse
Reactivity: Human
Immunogen: A human fusion protein was used as the immunogen for the Alpha Catenin antibody.
Format: Purified

Handling & Safety

Storage: +4°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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