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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-V4188SAF-100UG | 100 µg | - | - |
3 - 10 business days* |
752.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
1 mg/ml in 1X PBS, BSA free, sodium azide free. Crystallins are the major proteins of the... more
Product information "Anti-Alpha B Crystallin / CRYAB, clone CRYAB/4657"
1 mg/ml in 1X PBS, BSA free, sodium azide free. Crystallins are the major proteins of the vertebrate eye lens, where they maintain the transparency and refractive index of the lens. Crystallins are divided into Alpha, beta and gamma families, and the beta- and gamma-crystallins also compose a superfamily. Crystallins usually contain seven distinct protein regions, including four homologous motifs, a connecting peptide, and N- and C-terminal extensions. Alpha-crystallins consist of three gene products, AlphaA-, AlphaB- and AlphaC-crystallin, which are members of the small heat shock protein family (HSP 20). Alpha-crystallins act as molecular chaperones by holding denatured proteins in large soluble aggregates. However, unlike other molecular chaperones, Alpha-crystallins do not renature these proteins. Expression of AlphaA-crystallin is restricted to the lens and defects of this gene cause the development of autosomal dominant congenital cataracts (ADCC). The human AlphaB-crystallin gene product is expressed in many tissues, including lens, heart and skeletal muscle. Elevated expression of AlphaB-crystallin is associated with many neurological diseases, and a missense mutation in this gene has co-segregated in a family with a Desmin-related myopathy. Protein function: May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions. In lens epithelial cells, stabilizes the ATP6V1A protein, preventing its degradation by the proteasome. [The UniProt Consortium]
Keywords: | Anti-CRYA2, Anti-HspB5, Anti-Alpha(B)-crystallin, Anti-Alpha-crystallin B chain, Anti-Rosenthal fiber component, Anti-Heat shock protein beta-5, Anti-Renal carcinoma antigen NY-REN-27, Alpha B Crystallin Antibody / CRYAB |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | V4188SAF |
Properties
Application: | WB, IHC (paraffin) |
Antibody Type: | Monoclonal |
Clone: | CRYAB/4657 |
Conjugate: | No |
Host: | Mouse |
Species reactivity: | human |
Immunogen: | Recombinant human full-length CRYAB protein |
Format: | Purified |
Database Information
KEGG ID : | K09542 | Matching products |
UniProt ID : | P02511 | Matching products |
Gene ID | GeneID 1410 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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