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This gene encodes a member of the glycosyltransferase 1 family. The encoded protein acts as an alpha 1,3 mannosyltransferase, mannosylating Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. Defects in this gene have been associated with congenital disorder of glycosylation type Ih (CDG-Ii). Alternative splicing results in multiple transcript variants. Protein function: Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. [The UniProt Consortium]
Keywords:
Anti-ALG2, EC=2.4.1.132, EC=2.4.1.257, Anti-Alpha-1,3/1,6-mannosyltransferase ALG2, Anti-Asparagine-linked glycosylation protein 2 homolog, Anti-GDP-Man:Man(1)GlcNAc(2)-PP-dolichol mannosyltransferase, Anti-GDP-Man:Man(1)GlcNAc(2)-PP-Dol alpha-1, ALG2 Pol
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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