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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
NSJ-RQ5492 | 100 µl | - | - |
3 - 10 business days* |
755.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. AKT1S1 is a substrate... more
Product information "Anti-AKT1S1 / PRAS40, clone ABIO-1"
Antibody in PBS with 0.02% sodium azide, 50% glycerol and 0.4-0.5mg/ml BSA. AKT1S1 is a substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. It may also play a role in nerve growth factor-mediated neuroprotection. [UniProt] Protein function: Negative regulator of the mechanistic target of rapamycin complex 1 (mTORC1), an evolutionarily conserved central nutrient sensor that stimulates anabolic reactions and macromolecule biosynthesis to promote cellular biomass generation and growth (PubMed:17510057, PubMed:17386266, PubMed:17277771, PubMed:29236692). In absence of insulin and nutrients, AKT1S1 associates with the mTORC1 complex and directly inhibits mTORC1 activity by blocking the MTOR substrate- recruitment site (PubMed:29236692). In response to insulin and nutrients, AKT1S1 dissociates from mTORC1 (PubMed:17386266, PubMed:18372248). Its activity is dependent on its phosphorylation state and binding to 14-3-3 (PubMed:16174443, PubMed:18372248). May also play a role in nerve growth factor-mediated neuroprotection. [The UniProt Consortium]
Keywords: | Anti-Proline-rich AKT1 substrate 1, Anti-40 kDa proline-rich AKT substrate, AKT1S1 Antibody / PRAS40 |
Supplier: | NSJ Bioreagents |
Supplier-Nr: | RQ5492 |
Properties
Application: | WB |
Antibody Type: | Monoclonal |
Clone: | ABIO-1 |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human |
Immunogen: | A synthetic peptide specific to human AKT1S1 / PRAS40 |
Format: | Purified |
Database Information
KEGG ID : | K16184 | Matching products |
UniProt ID : | Q96B36 | Matching products |
Gene ID | GeneID 84335 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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