Anti-AIRE (isoforms 1 + 2), Internal

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
ARG64102.100	100 µg		-	-	6 - 14 business days*		784.00€

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Protein function: Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but... more

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Product information "Anti-AIRE (isoforms 1 + 2), Internal"

Protein function: Transcriptional regulator that binds to DNA as a dimer or as a tetramer, but not as a monomer. Binds to G-doublets in an A/T-rich environment, the preferred motif is a tandem repeat of 5'-. ATTGGTTA-3' combined with a 5'-TTATTA-3' box. Binds to nucleosomes. Binds to chromatin and interacts selectively with histone H3 that is not methylated at 'Lys-4', not phosphorylated at 'Thr-3' and not methylated at 'Arg-2'. Functions as a sensor of histone H3 modifications that are important for the epigenetic regulation of gene expression. Functions as a transcriptional activator and promotes the expression of otherwise tissue-specific self-antigens in the thymus, which is important for self tolerance and the avoidance of autoimmune reactions. [The UniProt Consortium]

Keywords:	Anti-AIRE, Anti-APECED, Anti-APECED protein, Anti-Autoimmune regulator, Anti-Autoimmune polyendocrinopathy candidiasis ectodermal dystrophy protein
Supplier:	Arigo Biolaboratories
Supplier-Nr:	ARG64102

Properties

Application:	ELISA, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Goat
Species reactivity:	human, mouse (Expected: rat, swine, bovine)
Immunogen:	C-KAKPPKKPESSAEQ
Format:	Ammonium Sulfate Precipitated