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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ARG43133.50 | 50 µg | - | - |
6 - 14 business days* |
520.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Protein function: [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central... more
Product information "Anti-Agrin"
Protein function: [Isoform 1]: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. Component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This secreted isoform forms a bridge, after release from motor neurons, to basal lamina through binding laminin via the NtA domain. [The UniProt Consortium]
Keywords: | Anti-C90, Anti-C22, Anti-AGRN, Anti-AGRIN, Anti-Agrin, Anti-Agrin N-terminal 110 kDa subunit, Anti-Agrin C-terminal 110 kDa subunit, Anti-Agrin C-terminal 90 kDa fragment, Anti-Agrin C-terminal 22 kDa fragment |
Supplier: | Arigo Biolaboratories |
Supplier-Nr: | ARG43133 |
Properties
Application: | WB |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | mouse, rat (Expected: human) |
Immunogen: | Recombinant protein corresponding to S1864-P2068 of Human Agrin |
MW: | 217 kD |
Format: | Antigen Affinity Purified |
Database Information
KEGG ID : | K06254 | Matching products |
UniProt ID : | O00468 | Matching products |
Gene ID | GeneID 375790 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: °C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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