Anti-AGAP2 (Arf-GAP with GTPase, ANK Repeat and PH Domain-containing Protein 2, AGAP-2, Centaurin-ga

Anti-AGAP2 (Arf-GAP with GTPase, ANK Repeat and PH Domain-containing Protein 2, AGAP-2, Centaurin-ga
Item number Size Datasheet Manual SDS Delivery time Quantity Price
A0929-02.100 100 µg - -

3 - 19 business days*

629.00€
 
AGAP2 (also known as PIKE-A), a putative oncogene, shows elevated expression in cancer cells... more
Product information "Anti-AGAP2 (Arf-GAP with GTPase, ANK Repeat and PH Domain-containing Protein 2, AGAP-2, Centaurin-ga"
AGAP2 (also known as PIKE-A), a putative oncogene, shows elevated expression in cancer cells compared to non-transformed cells and has been implicated as regulators of cancer cell invasion into normal tissues. A contributor to brain, eye, breast and liver cancers, AGAP2 belongs to the centaurin gamma-like family with two ANK repeats, an Arf-GAP domain, a Miro domain and a PH domain. It is a GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. The Arf-GAP domain interacts with G domain and may regulate its GTPase activity. GAP activity of AGAP2 is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation. Several isoforms of AGAP2 have been reported. Applications: Suitable for use in Western Blot and Immunohistochemistry. Other applications not tested. Recommended Dilution: Western Blot: 2-3ug/ml, Immunohistochemistry (formalin fixed paraffin embedded): 5ug/ml, Optimal dilutions to be determined by the researcher. Storage and Stability: May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for at least 12 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
Keywords: Anti-Phosphatidylinositol-3-kinase enhancer, Anti-GTP-binding and GTPase-activating protein 2, Anti-Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2
Supplier: United States Biological
Supplier-Nr: A0929-02

Properties

Application: IHC, WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, monkey
Immunogen: Synthetic peptide corresponding to aa20-60 of human AGAP2.
Format: Affinity Purified

Handling & Safety

Storage: -20°C
Shipping: +4°C (International: +4°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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