Anti-PIKE

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
200-401-DN8	100 µg		-	-	6 - 10 business days*		684.00€

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Anti-PIKE Antibody is purified by ion exchange chromatography. Anti-PIKE will detect both PIKE-L... more

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Product information "Anti-PIKE"

Anti-PIKE Antibody is purified by ion exchange chromatography. Anti-PIKE will detect both PIKE-L and PIKE-A isoforms. Protein function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. [The UniProt Consortium]

Keywords:	Anti-PIKE, Anti-GGAP2, Anti-AGAP2, Anti-CENTG1, Anti-AGAP-2, Anti-Cnt-g1, Anti-Centaurin-gamma-1, Anti-Phosphatidylinositol 3-kinase enhancer, Anti-GTP-binding and GTPase-activating protein 2, Anti-Arf-GAP with GTPase, Anti-ANK repeat and PH domain-contai
Supplier:	Rockland Immunochemicals
Supplier-Nr:	200-401-DN8

Properties

Application:	ELISA, IHC, WB
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human, mouse
Immunogen:	Peptide corresponding to 15 amino acids near the C-terminus of human PIKE.
Format:	Purified