Anti-PIKE

Item number	Size	Datasheet	Manual	SDS	Delivery time	Quantity	Price
A304-263A-T	10 µl (10 µg)		-		2 - 8 business days*		164.00€
A304-263A	100 µl (100 µg)		-		2 - 8 business days*		588.00€

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Protein function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong... more

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Product information "Anti-PIKE"

Protein function: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. [The UniProt Consortium]

Keywords:	Anti-PIKE, Anti-AGAP2, Anti-GGAP2, Anti-CENTG1, Anti-Cnt-g1, Anti-AGAP-2, Anti-Centaurin-gamma-1, Anti-Phosphatidylinositol 3-kinase enhancer, Anti-GTP-binding and GTPase-activating protein 2, Anti-Arf-GAP with GTPase
Supplier:	Bethyl Laboratories
Supplier-Nr:	A304-263A

Properties

Application:	WB, IP
Antibody Type:	Polyclonal
Conjugate:	No
Host:	Rabbit
Species reactivity:	human (Expected: mouse, rat)
Immunogen:	synthetic peptide. The epitope recognized by A304-263A-T maps to a region between residue 700 to 750 of human Phosphatidylinositol-3-kinase Enhancer using the numbering given in entry NP_055585.1 (GeneID 116986).
Format:	Antigen Affinity Purified