Anti-ADARB1

Anti-ADARB1
Item number Size Datasheet Manual SDS Delivery time Quantity Price
E-AB-66927.60 60 µl -

7 - 16 business days*

198.00€
E-AB-66927.120 120 µl -

7 - 16 business days*

317.00€
E-AB-66927.200 200 µl -

7 - 16 business days*

525.00€
 
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B... more
Product information "Anti-ADARB1"
This gene encodes the enzyme responsible for pre-mRNA editing of the glutamate receptor subunit B by site-specific deamination of adenosines. Studies in rat found that this enzyme acted on its own pre-mRNA molecules to convert an AA dinucleotide to an AI dinucleotide which resulted in a new splice site. Alternative splicing of this gene results in several transcript variants, some of which have been characterized by the presence or absence of an ALU cassette insert and a short or long C-terminal region. Protein function: Catalyzes the hydrolytic deamination of adenosine to inosine in double-stranded RNA (dsRNA) referred to as A-to-I RNA editing. This may affect gene expression and function in a number of ways that include mRNA translation by changing codons and hence the amino acid sequence of proteins, pre-mRNA splicing by altering splice site recognition sequences, RNA stability by changing sequences involved in nuclease recognition, genetic stability in the case of RNA virus genomes by changing sequences during viral RNA replication, and RNA structure-dependent activities such as microRNA production or targeting or protein-RNA interactions. Can edit both viral and cellular RNAs and can edit RNAs at multiple sites (hyper-editing) or at specific sites (site-specific editing). Its cellular RNA substrates include: bladder cancer-associated protein (BLCAP), neurotransmitter receptors for glutamate (GRIA2 and GRIK2) and serotonin (HTR2C), GABA receptor (GABRA3) and potassium voltage-gated channel (KCNA1). Site-specific RNA editing of transcripts encoding these proteins results in amino acid substitutions which consequently alter their functional activities. Edits GRIA2 at both the Q/R and R/G sites efficiently but converts the adenosine in hotspot1 much less efficiently. Can exert a proviral effect towards human immunodeficiency virus type 1 (HIV-1) and enhances its replication via both an editing-dependent and editing-independent mechanism. The former involves editing of adenosines in the 5'UTR while the latter occurs via suppression of EIF2AK2/PKR activation and function. Can inhibit cell proliferation and migration and can stimulate exocytosis. [The UniProt Consortium]
Keywords: Anti-ADAR2, Anti-ADARB1, EC=3.5.4.37, Anti-RNA-editing enzyme 1, Anti-RNA-editing deaminase 1, Anti-dsRNA adenosine deaminase, Anti-Double-stranded RNA-specific editase 1, ADARB1 Polyclonal Antibody
Supplier: Elabscience
Supplier-Nr: E-AB-66927

Properties

Application: WB
Antibody Type: Polyclonal
Conjugate: No
Host: Rabbit
Species reactivity: human, mouse, rat
Immunogen: Recombinant fusion protein of human ADARB1 (NP_001103.1).

Handling & Safety

Storage: -20°C
Shipping: 4°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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