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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
ELK-ES1581.50 | 50 µl | - | - |
Request delivery time estimate |
169.00€
|
||
ELK-ES1581.100 | 100 µl | - | - |
Request delivery time estimate |
283.00€
|
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
function:Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist... more
Product information "Anti-AChRalpha10"
function:Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma.,miscellaneous:The hetero-oligomeric receptor composed of CHRNA9 and CHRNA10 has an atypical pharmacological profile, binding several non-nicotinic ligands including strychnine (a glycine receptor antagonist) and atropine (a muscarinic acetylcholine receptor antagonist).,similarity:Belongs to the ligand-gated ionic channel (TC 1.A.9) family.,subunit:Forms hetero-oligomeric channels in conjunction with CHRNA9. The native outer hair cell receptor may be composed of CHRNA9-CHRNA10 hetero-oligomers.,tissue specificity:Expressed in inner-ear tissue, tonsil, immortalized B-cells, cultured T-cells and peripheral blood lymphocytes., Protein function: Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion- conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium, the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear, this may lead to a reduction in basilar membrane motion, altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. [The UniProt Consortium] Recommended dilutions: Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.. Cellular localization: Cell junction, synapse, postsynaptic cell membrane , Multi-pass membrane protein . Cell membrane , Multi-pass membrane protein .
Keywords: | Anti-CHRNA10, Anti-NACHRA10, Anti-NACHR alpha-10, Anti-Neuronal acetylcholine receptor subunit alpha-10, Anti-Nicotinic acetylcholine receptor subunit alpha-10, AChRalpha10 rabbit pAb |
Supplier: | ELK Biotechnology |
Supplier-Nr: | ES1581 |
Properties
Application: | WB, ELISA |
Antibody Type: | Polyclonal |
Conjugate: | No |
Host: | Rabbit |
Species reactivity: | human, mouse, rat |
Immunogen: | The antiserum was produced against synthesized peptide derived from human CHRNA10. AA range:394-443 |
MW: | 50 kD |
Format: | Antiserum |
Database Information
KEGG ID : | K04811 | Matching products |
UniProt ID : | Q9GZZ6 | Matching products |
Gene ID | GeneID 57053 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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